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KMID : 0613820110210101422
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Journal of Life Science
2011 Volume.21 No. 10 p.1422 ~ p.1427
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Antithrombotic and Antiplatelet Activity of Extract from Prunella vulgaris
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Yang Won-Kyung
Sung Yoon-Young
Kim Ho-Kyoung
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Abstract
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This study was performed to develop effective antithrombotic agents from traditional herb extracts. Prunella vulgaris L. has been used traditionally as a medical resource in cancer therapy, as well as treatment of hypertension and inflammation, and as a diuretic. However, the effects of Prunella vulgaris on thrombosis and platelet activation have not been clearly understood. Antithrombotic and antiplatelet activities of oriental medicinal herbs were investigated by evaluating the effect of the aqueous extract from Prunella vulgaris on the blood coagulation, platelet aggregation and fibrinolysis. Prunella vulgaris extracts showed effective anticoagulant activity in coagulation times such as activated partial thromboplastin time (APTT) and prothrombin time (PT). Prunella vulgaris also inhibited adenosine diphosphate (ADP)- and collagen-induced platelet aggregation. In addition, evaluation of fibrinolytic activity showed that the Prunella vulgaris extracts have high solubility. From these results, it is suggested that Prunella vulgaris can be a potential candidate for anticoagulants and antiplatelets, as well as fibrinolytic agents.
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KEYWORD
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Antithrombotic, platelet aggregation, blood coagulation, fibrinolysis, Prunella vulgaris
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